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Life style change in acne

Introduce such foods

To augument Fox01                                                                               To attenuate m Torc

Salad                                                                                                            Omega 3 fatty acids

Vegetable                                                                                                      Sea fish

Green tea                                                                                                      Salads

Curcumin                                                                                                      Vegetables

Resveretol                                                                                                     Berries

Green tea

Curcumin

 

Explanation

  • Sugar : post – prandial hyperinsuliemia
  • Sweet : insulin – mediated hyperglycemia Reduction in IGFBP3
  • Soft drinks : increase in free-circulatingt IGF1
  • Pasta :  reduce nuclear activity of Fox01
  • White flour : increased expression of SREBP- 1c
  • 200 Patients

 

Do you think foods aggravate your

  • Yes-52.2%
  • Maybe-13.3%
  • No-34.5%

Targeting insulin resistance may be an interesting treatment option for sebo-suppression.

Another important aspect may be to follow acne patients temporally to determine whether they are an increased risk of future development of diabetes which insulin resistance is a precursor .

 

Conclusions

Insulin resistance is global epidemic. Available evidence suggests that acne is associated with insulin resistance . Causality and causal pathways between insulin resistance and acne formation needs to be determined by robust studies. Available evidence suggests that acnegenesis is medaited through IGF-1. Isotretinoin on insulin resistance Isotretinonin causes hypertriglyceridemia which is casusally related to insulin resistance. Studies did not find isotretinoin to alter insulin sensitivity significantly. Hypertriglyceridemia associated insulin resistance primar occurs when lipid is delivered and accumulates in the Isotretinoin only prevents clearance of triglyceride rich Vitamins from blood into tissues. Exercise on insulin resistance. Accumulated daily physical activity is a major determinate of insulin sensitivity. Exercise leads to translocation of GLUT-4 to cell membranes non insulin dependent and this action is not followings IRS-1 pathway. Time spent sedentary ,time spent in light-activity and bouts of moderate or vigorous activity does not impact insulin sensitivity independently of total activity.

Hormonal changes in insulin resistance

  • Increased insulin
  • increased IGF-1 Influences
  • Gonadal and adrenal androgen synthesis
  • Stimulate 5a reductase
  • Androgen receptor signaling
  • Sebocyte proliferation and lipogenesis
  • How does insulin resistance develop?
  • Accumulation of by-products of nutritional overload in insulin sensitive tissue.
  • Endoplasmic reticulum stress
  • Inflammation
  • Hormonal factors

What is insulin resistance?

Reduce sensitivity of metabolic pathway of insulin action after binding to insulin receptor leading to impaired gluscose transport glycogen synthesis and augmented glucose oxidation.

  • Chronologic evolution of insulin resistance
  • Sugar Cravings
  • Obesity/inability to lose weight
  • Darkening of skin/SOSQ
  • Acne /androgen excess
  • Persistence of acne (adult acne) , Melasma
  • Adult acne with patterned hair loss
  • Adult acne +metabolic syndrome
  • Adult acne +metabolic syndrome +cancer?
  • Metabolic Syndrome :Natural Evolution
  • Low birth weight
  • Excessive weight gain childhood
  • premature pubarche
  • allergic diathesis
  • acanthosis nigricans
  • striae
  • gynecomastia

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